文章基本信息

标题：The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits
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作者：Aldons J. Lusis ; Marcus M. Seldin ; Hooman Allayee 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2016
卷号：57
期号：6
页码：925-942
DOI：10.1194/jlr.R066944
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.
关键词：aherosclerosis ; osteoporosis ; obesity ; heart failure ; microbiota ; gene-by-diet interaction ; gene expression ; insulin resistance ; gene mapping