文章基本信息

标题：Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR:LA-cp rat
本地全文：下载
作者：Miriam Jacome-Sosa ; Claudia Vacca ; Rabban Mangat 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2016
卷号：57
期号：4
页码：638-649
DOI：10.1194/jlr.M066308
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Vaccenic acid (VA), the predominant ruminant-derived trans fat in the food chain, ameliorates hyperlipidemia, yet mechanisms remain elusive. We investigated whether VA could influence tissue endocannabinoids (ECs) by altering the availability of their biosynthetic precursor, arachidonic acid (AA), in membrane phospholipids (PLs). JCR:LA -cp rats were assigned to a control diet with or without VA (1% w/w), cis -9, trans -11 conjugated linoleic acid (CLA) (1% w/w) or VA+CLA (1% + 0.5% w/w) for 8 weeks. VA reduced the EC, 2-arachidonoylglycerol (2-AG), in the liver and visceral adipose tissue (VAT) relative to control diet ( P P > 0.05). Interestingly, VA increased jejunal concentrations of anandamide and those of the noncannabinoid signaling molecules, oleoylethanolamide and palmitoylethanolamide, relative to control diet ( P P
关键词：vaccenic acid ; endocannabinoids ; N -acylethanolamines ; intestinal inflammatory diseases ; anandamide