文章基本信息

标题：Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery
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作者：Emmanuel Akintoye ; Jason H. Y. Wu ; Tao Hou 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2016
卷号：57
期号：3
页码：492-498
DOI：10.1194/jlr.P062398
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Patients (479) undergoing cardiac surgery in three countries were randomized to perioperative fish oil (EPA + DHA; 8–10 g over 2–5 days preoperatively, then 2 g/day postoperatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFAs were measured 2 days postoperatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined substantially following surgery (at postoperative day 2), with declines ranging from 37% to 63% ( P P ≤ 0.004). The n-3 PUFA supplementation did not significantly alter the decline in n-6 PUFA-derived MEFAs. Both enrollment level and changes in plasma phospholipid EPA and DHA were associated with their respective MEFAs at postoperative day 2 ( P
关键词：diet and dietary lipids ; inflammation ; omega-3 fatty acids ; phospholipids ; vascular biology ; randomized controlled trial