文章基本信息

标题：FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue
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作者：Maija Vaittinen ; Paula Walle ; Emmi Kuosmanen 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2016
卷号：57
期号：1
页码：56-65
DOI：10.1194/jlr.M059113
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Obesity is associated with disturbed lipid metabolism and low-grade inflammation in tissues. The aim of this study was to investigate the association between FA metabolism and adipose tissue (AT) inflammation in the Kuopio Obesity Surgery study. We investigated the association of surgery-induced weight loss and FA desaturase ( FADS ) 1/2 genotypes with serum and AT FA profile and with AT inflammation, measured as interleukin ( IL ) -1β and NFκB pathway gene expression, in order to find potential gene-environment interactions. We demonstrated an association between serum levels of saturated and polyunsaturated n-6 FAs, and estimated enzyme activities of FADS1/2 genes with IL-1β expression in AT both at baseline and at follow-up. Variation in the FADS1/2 genes associated with IL-1β and NFκB pathway gene expression in SAT after weight reduction, but not at baseline. In addition, the FA composition in subcutaneous and visceral fat correlated with serum FAs, and the associations between serum PUFAs and estimated D6D enzyme activity with AT inflammation were also replicated with corresponding AT FAs and AT inflammation. We conclude that the polymorphism in FADS1/2 genes associates with FA metabolism and AT inflammation, leading to an interaction between weight loss and FADS1/2 genes in the regulation of AT inflammation.
关键词：fatty acid ; fatty acid/desaturases ; fatty acid/metabolism ; gene expression ; genetics ; obesity ; fatty acid desaturase 1