文章基本信息

标题：The effect of phospholipid composition of reconstituted HDL on its cholesterol efflux and anti-inflammatory properties
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作者：Anna Schwendeman ; Denis O. Sviridov ; Wenmin Yuan 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2015
卷号：56
期号：9
页码：1727-1737
DOI：10.1194/jlr.M060285
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The goal of this study was to understand how the reconstituted HDL (rHDL) phospholipid (PL) composition affects its cholesterol efflux and anti-inflammatory properties. An ApoA-I mimetic peptide, 5A, was combined with either SM or POPC. Both lipid formulations exhibited similar in vitro cholesterol efflux by ABCA1, but 5A-SM exhibited higher ABCG1- and SR-BI-mediated efflux relative to 5A-POPC ( P P −/− mice, but only 5A-SM showed a statistically significant reduction over placebo control and baseline ( P
关键词：high density lipoprotein ; apolipoprotein A-I ; sphingomyelin ; peptides ; inflammation ; atherosclerosis