文章基本信息

标题：Intestinal nuclear receptors in HDL cholesterol metabolism
本地全文：下载
作者：Chiara Degirolamo ; Carlo Sabbà ; Antonio Moschetta 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2015
卷号：56
期号：7
页码：1262-1270
DOI：10.1194/jlr.R052704
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The intestine plays a pivotal role in cholesterol homeostasis by functioning as an absorptive and secretory organ in the reverse cholesterol transport pathway. Enterocytes control cholesterol absorption, apoAI synthesis, HDL biogenesis, and nonbiliary cholesterol fecal disposal. Thus, intestine-based therapeutic interventions may hold promise in the management of diseases driven by cholesterol overload. Lipid-sensing nuclear receptors (NRs) are highly expressed in the intestinal epithelium and regulate transcriptionally the handling of cholesterol by the enterocytes. Here, we discuss the NR regulation of cholesterol fluxes across the enterocytes with special emphasis on NR exploitation as a bona fide novel HDL-raising strategy.
关键词：atherosclerosis ; gene expression ; lipoprotein ; transport ; transcription ; high density lipoprotein