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标题：HDL-apolipoprotein A-I exchange is independently associated with cholesterol efflux capacity
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作者：Mark S. Borja ; Kit F. Ng ; Angela Irwin 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2015
卷号：56
期号：10
页码：2002-2009
DOI：10.1194/jlr.M059865
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：HDL is the primary mediator of cholesterol mobilization from the periphery to the liver via reverse cholesterol transport (RCT). A critical first step in this process is the uptake of cholesterol from lipid-loaded macrophages by HDL, a function of HDL inversely associated with prevalent and incident cardiovascular disease. We hypothesized that the dynamic ability of HDL to undergo remodeling and exchange of apoA-I is an important and potentially rate-limiting aspect of RCT. In this study, we investigated the relationship between HDL-apoA-I exchange (HAE) and serum HDL cholesterol (HDL-C) efflux capacity. We compared HAE to the total and ABCA1-specific cholesterol efflux capacity of 77 subjects. We found that HAE was highly correlated with both total ( r = 0.69, P r = 0.47, P
关键词：high density lipoprotein ; high density lipoprotein/metabolism ; lipoproteins ; ATP binding cassette transporter A1 ; high density lipoprotein remodeling/exchange