文章基本信息

标题：Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction
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作者：Sin Man Lam ; Louis Tong ; Xinrui Duan 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2014
卷号：55
期号：9
页码：1959-1969
DOI：10.1194/jlr.P051185
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye and ocular discomfort characterized by an unstable tear film principally attributed to afflicted delivery of lipids to the ocular surface. Herein, we elucidated longitudinal tear lipid alterations associated with disease alleviation and symptom improvement in a cohort of MGD patients undergoing eyelid-warming treatment for 12 weeks. Remarkably, eyelid-warming resulted in stark reductions in lysophospholipids ( P P O -acyl- ω -hydroxy-FAs (OAHFAs), which are lipid amphiphiles critical to the maintenance of tear film stability. Longitudinal changes in the tear lipids aforementioned also significantly ( P
关键词：dry eye ; tear lipidomics ; lysophospholipids ; O-acyl-omega-hydroxy fatty acids