文章基本信息

标题：Bone marrow-derived HL mitigates bone marrow-derived CETP-mediated decreases in HDL in mice globally deficient in HL and the LDLr
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作者：Neil J. Hime ; Audrey S. Black ; David J. Bonnet 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2014
卷号：55
期号：9
页码：1864-1875
DOI：10.1194/jlr.M046318
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The objective of this study was to determine the combined effects of HL and cholesteryl ester transfer protein (CETP), derived exclusively from bone marrow (BM), on plasma lipids and atherosclerosis in high-fat-fed, atherosclerosis-prone mice. We transferred BM expressing these proteins into male and female double-knockout HL-deficient, LDL receptor-deficient mice (HL^−/−LDLr^−/−). Four BM chimeras were generated, where BM-derived cells expressed 1 ) HL but not CETP, 2 ) CETP and HL, 3 ) CETP but not HL, or 4 ) neither CETP nor HL. After high-fat feeding, plasma HDL-cholesterol (HDL-C) was decreased in mice with BM expressing CETP but not HL (17 ± 4 and 19 ± 3 mg/dl, female and male mice, respectively) compared with mice with BM expressing neither CETP nor HL (87 ± 3 and 95 ± 4 mg/dl, female and male mice, respectively, P
关键词：cholesteryl ester transfer protein ; hepatic lipase ; high density lipoprotein ; atherosclerosis ; cholesterol ; low density lipoprotein receptor