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标题：Serum choline plasmalogens, particularly those with oleic acid in sn-2, are associated with proatherogenic state
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作者：Megumi Nishimukai ; Ryouta Maeba ; Yuya Yamazaki 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2014
卷号：55
期号：5
页码：956-965
DOI：10.1194/jlr.P045591
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Serum plasmalogens (Pls) (1- O -alk-1’-enyl-2-acyl glycerophospholipids) are of particular interest for studies on metabolic disorders associated with oxidative stress and chronic inflammation. Serum levels of Pls are known to correlate positively with HDL-cholesterol (HDL-C); however, few studies have examined serum Pls molecular species in association with pathophysiological conditions and their clinical significance. To clarify these, we determined serum levels of individual ether glycerophospholipids in Japanese asymptomatic cohorts (n = 428; 362 male and 66 female subjects) by LC/MS/MS, and examined their correlations with clinical parameters. We found that the proportion of choline Pls (PlsCho) among total serum phospholipids was significantly lower in the male group over 40 years old and was associated with multiple risk parameters more strongly than HDL-C. The abundance of serum PlsCho with oleic acid (18:1) in sn -2 exhibited the strongest positive correlation with serum concentrations of adiponectin and HDL-C, while being inversely associated with waist circumference and the serum levels of TG and small dense LDL-cholesterol. The characterization of serum ether glycerophospholipids verified the specificity of PlsCho, particularly the ones with 18:1 in sn -2, as a sensitive biomarker for the atherogenic state.
关键词：ether glycerophospholipid ; high density lipoprotein-cholesterol ; atherosclerosis ; serum biomarker