文章基本信息

标题：Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
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作者：Daisuke Hishikawa ; Tomomi Hashidate ; Takao Shimizu 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2014
卷号：55
期号：5
页码：799-807
DOI：10.1194/jlr.R046094
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Cellular membranes are composed of numerous kinds of glycerophospholipids with different combinations of polar heads at the sn -3 position and acyl moieties at the sn -1 and sn -2 positions, respectively. The glycerophospholipid compositions of different cell types, organelles, and inner/outer plasma membrane leaflets are quite diverse. The acyl moieties of glycerophospholipids synthesized in the de novo pathway are subsequently remodeled by the action of phospholipases and lysophospholipid acyltransferases. This remodeling cycle contributes to the generation of membrane glycerophospholipid diversity and the production of lipid mediators such as fatty acid derivatives and lysophospholipids. Furthermore, specific glycerophospholipid transporters are also important to organize a unique glycerophospholipid composition in each organelle. Recent progress in this field contributes to understanding how and why membrane glycerophospholipid diversity is organized and maintained.
关键词：lysophospholipid acyltransferase ; membrane biology ; phospholipid metabolism