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标题：Modulation of plasma N-acylethanolamine levels and physiological parameters by dietary fatty acid composition in humans
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作者：Peter J. H. Jones ; Lin Lin ; Leah G. Gillingham 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2014
卷号：55
期号：12
页码：2655-2664
DOI：10.1194/jlr.P051235
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：N -acylethanolamines (NAEs) are endogenous lipid-signaling molecules involved in satiety and energetics; however, how diet impacts circulating NAE concentrations and their downstream metabolic actions in humans remains unknown. Objectives were to examine effects of diets enriched with high-oleic canola oil (HOCO) or HOCO blended with flaxseed oil (FXCO), compared with a Western diet (WD), on plasma NAE levels and the association with energy expenditure and substrate oxidation. Using a randomized controlled crossover design, 36 hypercholesterolemic participants consumed three isoenergetic diets for 28 days, each containing 36% energy from fat, of which 70% was HOCO, FXCO, or WD. Ultra-performance liquid chromatography-MS/MS was used to measure plasma NAE levels and indirect calorimetry to assess energy expenditure and substrate oxidation. After 28 days, compared with WD, plasma oleoylethanolamide (OEA) and alpha-linolenoyl ethanolamide (ALEA) levels were significantly increased in response to HOCO and FXCO ( P = 0.002, P r = −0.21, P = 0.04), and a positive association was observed between the plasma arachidonoyl ethanolamide (AEA)/OEA ratio and android:gynoid fat ( r = 0.23, P = 0.02), respectively. Results suggest that plasma NAE levels are upregulated via their dietary lipid substrates and may modulate regional and total fat mass through lipid-signaling mechanisms.
关键词：endocannabinoids ; clinical trials ; fatty acid metabolism ; fatty acid oxidation ; peroxisome proliferator-activated receptor ; oleoylethanolamide ; canola oil ; oleic acid ; arachidonoylethanolamide ; body composition