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标题：Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study
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作者：Annelise Genoux ; Jean-Bernard Ruidavets ; Jean Ferrières 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2013
卷号：54
期号：9
页码：2550-2558
DOI：10.1194/jlr.P036335
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：HDL is strongly inversely related to cardiovascular risk. Hepatic HDL uptake is controlled by ecto-F₁-ATPase activity, and potentially inhibited by mitochondrial inhibitor factor 1 (IF1). We recently found that IF1 is present in serum and correlates with HDL-cholesterol (HDL-C). Here, we have evaluated the relationship between circulating IF1 and plasma lipoproteins, and we determined whether IF1 concentration is associated with the risk of coronary heart disease (CHD). Serum IF1 was measured in 648 coronary patients ages 45–74 and in 669 matched male controls, in the context of a cross-sectional study on CHD. Cardiovascular risk factors were documented for each participant, including life-style habits and biological and clinical markers. In controls, multivariate analysis demonstrated that IF1 was independently positively associated with HDL-C and apoA-I ( r = 0.27 and 0.28, respectively, P r = −0.23, P P P
关键词：HDL-cholesterol ; coronary heart disease ; ATP-synthase inhibitor factor 1 ; nucleotide receptor P2Y₁₃ ; inhibitor factor 1