文章基本信息

标题：Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta
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作者：Megan L. Jones ; Peter J. Mark ; Jeffrey A. Keelan 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2013
卷号：54
期号：8
页码：2247-2254
DOI：10.1194/jlr.M039842
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Placental inflammation is associated with several pregnancy disorders. Inflammation is limited by anti-inflammatory and proresolving mechanisms, the latter partly mediated by resolvins and protectins derived from omega-3 polyunsaturated fatty acids (n-3PUFA). We examined effects of dietary n-3PUFAs on levels of resolvins, protectins, and lipoxygenase (ALOX) enzymes in the rat placenta. Rats consumed standard (Std) or high n-3PUFA (Hn3) diets from day 1 of pregnancy; tissues were collected on day 17 or 22 (term = day 23). Maternal Hn3 diet increased resolvin and protectin precursors, 18R/S-HEPE ( P P P Alox15b and Alox5 mRNA expression, while RvD2 increased at both days ( P P Alox15 mRNA expression ( P P Il1β , and Il6 mRNA expression increased marginally with Hn3 at day 22 ( P Ptgs1 ( Cox1 ) expression increased both days ( P
关键词：n-3PUFA ; inflammation ; pregnancy ; lipoxygenase