文章基本信息

标题：Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice
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作者：Thomas Gautier ; Willeke de Haan ; Jacques Grober 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2013
卷号：54
期号：8
页码：2195-2205
DOI：10.1194/jlr.M038141
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low. This study tested the hypothesis that FXR-mediated induction of CETP contributes to this phenotype. Patients with cholestasis and high plasma BA had lower HDL-C levels and higher plasma CETP activity and mass compared with matched controls with low plasma BA (each P P P P
关键词：nuclear receptor ; lipoproteins ; bile acids ; hepatocyte ; macrophage