文章基本信息

标题：Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm
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作者：Mercedes Camacho ; Jaume Dilmé ; David Solà-Villà 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2013
卷号：54
期号：12
页码：3506-3515
DOI：10.1194/jlr.M042481
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：We investigated the prostaglandin (PG)E₂ pathway in human abdominal aortic aneurysm (AAA) and its relationship with hypervascularization. We analyzed samples from patients undergoing AAA repair in comparison with those from healthy multiorgan donors. Patients were stratified according to maximum aortic diameter: low diameter (LD) ( 2 metabolites were higher in AAA than in controls (plasma-controls, 19.9 ± 2.2; plasma-AAA, 38.8 ± 5.5 pg/ml; secretion-normal aorta, 16.5 ± 6.4; secretion-AAA, 72.9 ± 6.4 pg/mg; mean ± SEM). E-prostanoid receptor (EP)-2 and EP-4 were overexpressed in AAA, EP-4 being the only EP substantially expressed and colocalized with mPGES-1 in the microvasculature. Additionally, EP-4 mediated PGE₂-induced angiogenesis in vitro. We provide new data concerning mPGES-1 expression in human AAA. Our findings suggest the potential relevance of the COX-2/mPGES-1/EP-4 axis in the AAA-associated hypervascularization.
关键词：cyclooxygenase pathway ; prostaglandin ; angiogenesis ; cyclooxygenase ; E prostanoid receptor ; microsomal isoform of prostaglandin E synthase