文章基本信息

标题：Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation
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作者：Annie Bouchard-Mercier ; Iwona Rudkowska ; Simone Lemieux 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2013
卷号：54
期号：10
页码：2866-2873
DOI：10.1194/jlr.M041590
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Interindividual variability in the response of plasma triglyceride concentrations (TG) following fish oil consumption has been observed. Our objective was to examine the associations between single-nucleotide polymorphisms (SNPs) within genes encoding proteins involved in de novo lipogenesis and the relative change in plasma TG levels following a fish oil supplementation. Two hundred and eight participants were recruited in the greater Quebec City area. The participants completed a six-week fish oil supplementation (5 g fish oil/day: 1.9–2.2 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid. SNPs within SREBF1 , ACLY , and ACACA genes were genotyped using TAQMAN methodology. After correction for multiple comparison, only two SNPs, rs8071753 ( ACLY ) and rs1714987 ( ACACA ), were associated with the relative change in plasma TG concentrations ( P = 0.004 and P = 0.005, respectively). These two SNPs explained 7.73% of the variance in plasma TG relative change following fish oil consumption. Genotype frequencies of rs8071753 according to the TG response groups (responders versus nonresponders) were different ( P = 0.02). We conclude that the presence of certain SNPs within genes, such as ACLY and ACACA , encoding proteins involved in de novo lipogenesis seem to influence the plasma TG response following fish oil consumption.
关键词：omega-3 polyunsaturated fatty acids ; fatty acid biosynthesis ; SREBF1 ; ACACA ; ACLY ; interindividual variability