文章基本信息

标题：Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice
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作者：Abdel K. Salous ; Manikandan Panchatcharam ; Manjula Sunkara 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2013
卷号：54
期号：10
页码：2775-2784
DOI：10.1194/jlr.M039685
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Lysophosphatidic acid (LPA) is a bioactive lipid mediator. Concentrations of the major LPA species in mouse plasma decreased uniformly following administration of a potent selective inhibitor of the LPA-generating lysophospholipase D autotaxin, identifying an active mechanism for removal of LPA from the circulation. LPA, akylglycerol phosphate (AGP), sphingosine 1-phosphate (S1P), and a variety of structural mimetics of these lipids, including phosphatase-resistant phosphonate analogs of LPA, were rapidly eliminated (t1/2
关键词：autotaxin ; lipid phosphate phosphatase ; transcellular uptake ; mass spectrometry