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标题：Effects of Therapeutic Lifestyle Change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects
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作者：Esther M. M. Ooi ; Alice H. Lichtenstein ; John S. Millar 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2012
卷号：53
期号：9
页码：1958-1967
DOI：10.1194/jlr.P024315
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The effects of Therapeutic Lifestyle Change (TLC) diets, low and high in dietary fish, on apolipoprotein metabolism were examined. Subjects were provided with a Western diet for 6 weeks, followed by 24 weeks of either of two TLC diets (10/group). Apolipoprotein kinetics were determined in the fed state using stable isotope methods and compartmental modeling at the end of each phase. Only the high-fish diet decreased median triglyceride-rich lipoprotein (TRL) apoB-100 concentration (−23%), production rate (PR, −9%), and direct catabolism (−53%), and increased TRL-to-LDL apoB-100 conversion (+39%) as compared with the baseline diet (all P P P
关键词：fatty acids ; hypercholesterolemia ; apolipoproteins ; dyslipidemias ; fish oil ; lipoproteins/linetics ; lipoproteins/metabolism ; nutrition ; omega-3 fatty acids ; mathematical modeling