文章基本信息

标题：Plasma apolipoprotein O level increased in the patients with acute coronary syndrome
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作者：Bi-lian Yu ; Chen-lu Wu ; Shui-ping Zhao 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2012
卷号：53
期号：9
页码：1952-1957
DOI：10.1194/jlr.P023028
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Apolipoprotein (apo) O is a novel apolipoprotein that is present predominantly in high density lipoprotein (HDL). However, overexpression of apoO does not impact on plasma HDL levels or functionality in human apoA-I transgenic mice. Thus, the physiological function of apoO is not yet known. In the present study, we investigated relationships between plasma apoO levels and high-sensitive C-reactive protein (hs-CRP) levels, as well as other lipid parameters in healthy subjects (n = 111) and patients with established acute coronary syndrome (ACS) (n = 50). ApoO was measured by the sandwich dot-blot technique with recombinant apoO as a protein standard. Mean apoO level in healthy subjects was 2.21 ± 0.83 µg/ml whereas it was 4.94 ± 1.59 µg/ml in ACS patients. There were significant differences in plasma level of apoO between two groups ( P r = 0.48, P P
关键词：apolipoproteins ; atherosclerosis ; high density lipoprotein ; inflammation ; lipoproteins