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标题：Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism
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作者：Margaret R. Diffenderfer ; Margaret E. Brousseau ; John S. Millar 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2012
卷号：53
期号：6
页码：1190-1199
DOI：10.1194/jlr.M019570
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Cholesteryl ester transfer protein (CETP) facilitates the transfer of HDL cholesteryl ester to triglyceride-rich lipoproteins (TRL). This study aimed to determine the effects of CETP inhibition with torcetrapib on TRL composition and apoB-48 metabolism. Study subjects with low HDL cholesterol ( 2H₃]L-leucine, while in the constantly fed state, to determine the kinetics of TRL apoB-48 and TRL composition. Relative to placebo, torcetrapib markedly reduced TRL CE levels in all groups (≥−69%; P P = 0.007; PR: −49%, P = 0.005) and twice daily (PS: −30%, P = 0.01; PR: −27%, P = 0.13) cohorts. In the atorvastatin cohort, apoB-48 PS and PR, which were already lowered by atorvastatin, did not change with torcetrapib. Our findings indicate that CETP inhibition reduced plasma apoB-48 concentrations by reducing apoB-48 production but did not have this effect in subjects already treated with atorvastatin.
关键词：cholesteryl ester transfer protein ; apolipoprotein ; lipoprotein kinetics ; postprandial metabolism ; torcetrapib