文章基本信息

标题：The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects
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作者：Marta Yanina Pepino ; Latisha Love-Gregory ; Samuel Klein 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2012
卷号：53
期号：3
页码：561-566
DOI：10.1194/jlr.M021873
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The precise orosensory inputs engaged for dietary lipids detection in humans are unknown. We evaluated whether a common single nucleotide polymorphism (rs1761667) in the CD36 gene that reduces CD36 expression and the addition of orlistat, a lipase inhibitor, to reduce FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate fat orosensory sensitivity in humans. Twenty-one obese subjects with different rs1761667 genotypes (6 AA, 7 AG, and 8 GG) were studied on two occasions in which oleic acid and triolein orosensory detection thresholds were measured using emulsions prepared with and without orlistat. Subjects homozygous for the G-allele had 8-fold lower oral detection thresholds for oleic acid and triolein than subjects homozygous for the A allele, which associates with lower CD36 expression ( P = 0.03). Thresholds for heterozygous subjects were intermediate. The addition of orlistat increased detection thresholds for triolein (log threshold = −0.3 ± 0.2 vs. 0.3 ± 0.1; P P > 0.2). In conclusion, this is the first experimental evidence for a role of CD36 in fat gustatory perception in humans. The data also support involvement of lingual lipase and are consistent with the concept that FA and not TG is the sensed stimulus.
关键词：diet and dietary lipids ; genetics ; lipids ; obesity ; triglycerides ; fat oral sensitivity ; taste perception