文章基本信息

标题：Dietary cholesterol increases paraoxonase 1 enzyme activity
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作者：Daniel S. Kim ; Amber A. Burt ; Jane E. Ranchalis 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2012
卷号：53
期号：11
页码：2450-2458
DOI：10.1194/jlr.P030601
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk (CLEAR) cohort. The goal of this study was to replicate these findings and determine whether other nutrient intake affected PON1 activity. To predict nutrient and mineral intake values, 1,402 subjects completed a standardized food frequency survey of their dietary habits over the past year. Stepwise regression was used to evaluate dietary and covariate effects on PON1 arylesterase activity. Five dietary components, cholesterol ( P −16), alcohol ( P = 8.51 × 10⁻⁸), vitamin C ( P = 7.97 × 10⁻⁵), iron ( P = 0.0026), and folic acid (0.037) were independently predictive of PON1 activity. Dietary cholesterol was positively associated and predicted 5.5% of PON1 activity, second in variance explained. This study presents a novel finding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confirms prior reported associations, including that with vitamin C. Identifying and understanding environmental factors that affect PON1 activity is necessary to understand its role and that of HDL in human disease.
关键词：cholesterol/dietary ; diet ; dietary lipids ; folate ; LDL/oxidation/antioxidants ; nutrition ; iron ; vitamin C