文章基本信息

标题：Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis
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作者：Boris L. Vaisman ; Stephen J. Demosky ; John A. Stonik 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2012
卷号：53
期号：1
页码：158-167
DOI：10.1194/jlr.M018713
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The role of endothelial ABCA1 expression in reverse cholesterol transport (RCT) was examined in transgenic mice, using the endothelial-specific Tie2 promoter. Human ABCA1 (hABCA1) was significantly expressed in endothelial cells (EC) of most tissues except the liver. Increased expression of ABCA1 was not observed in resident peritoneal macrophages. ApoA-I-mediated cholesterol efflux from aortic EC was 2.6-fold higher ( P P P P P ApoE or Abca1 knockout mice. In summary, expression of hABCA1 in EC appears to play a role in decreasing diet-induced atherosclerosis in mice and is associated with increased plasma HDL-C levels and beneficial gene expression changes in EC.
关键词：endothelial cells ; cholesterol efflux ; reverse cholesterol transport ; high density lipoprotein ; ATP binding cassette transporter A1