文章基本信息

标题：Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
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作者：Maartje E. Visser ; Fatima Akdim ; Diane L. Tribble 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2010
卷号：51
期号：5
页码：1057-1062
DOI：10.1194/jlr.M002915
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：To investigate the impact of mipomersen, an apolipoprotein B-100 (apoB) synthesis inhibitor, on intra-hepatic triglyceride content (IHTG content), we conducted a randomized, double-blind, placebo-controlled study in 21 patients with familial hypercholesterolemia (FH). Subjects received a weekly subcutaneous dose of 200 mg mipomersen or placebo for 13 weeks while continuing conventional lipid lowering therapy. The primary endpoint was change in IHTG content from week 0 to week 15 as measured by localized proton magnetic resonance spectroscopy (1H-MRS). Thirteen weeks of mipomersen administration reduced LDL-cholesterol by 22.0 (17.8) % and apoB by 19.9 (17.4) % (both P
关键词：antisense oligonucleotides ; drug therapy ; familial hypobetalipoproteinemia ; hepatic steatosis ; LDL-cholesterol ; localized proton magnetic resonance spectroscopy ; mipomersen