文章基本信息

标题：APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians
本地全文：下载
作者：Piya Lahiry ; Henian Cao ; Matthew R. Ban 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2010
卷号：51
期号：4
页码：843-848
DOI：10.1194/jlr.P002014
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Apolipoprotein (apo) C-I is a constituent of chylomicrons, very low density lipoprotein, and high density lipoprotein. The role of apo C-I in human metabolism is incompletely defined. We took advantage of a naturally occurring amino acid polymorphism that is present in aboriginal North Americans, namely apo C-I T45S. We assessed the hypothesis that metabolic traits, including obesity-related and lipoprotein-related traits, would differ between carriers and noncarriers of apo C-I T45S. A genotyping assay was developed for APOC1 T45S and genotypes were determined in a sample of 410 Canadian Oji-Cree subjects. The allele frequency of the apo C-I S45 allele was ∼8% in this sample. We observed the apo C-I S45 allele was significantly associated with 1 ) lower percent body fat ( P 2 ) lower waist circumference ( P = 0.058), 3 ) lower serum leptin levels ( P 4 ) lower plasma apo C-I levels ( P
关键词：nonsynonymous variant ; leptin ; Canadian First Nation population ; genetics ; serum levels ; hypertriglyceridemic waist