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标题：Phytosterol plasma concentrations and coronary heart disease in the prospective Spanish EPIC cohort
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作者：Verónica Escurriol ; Montserrat Cofán ; Concepción Moreno-Iribas 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2010
卷号：51
期号：3
页码：618-624
DOI：10.1194/jlr.P000471
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Phytosterol intake with natural foods, a measure of healthy dietary choices, increases plasma levels, but increased plasma phytosterols are believed to be a coronary heart disease (CHD) risk factor. To address this paradox, we evaluated baseline risk factors, phytosterol intake, and plasma noncholesterol sterol levels in participants of a case control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort who developed CHD (n = 299) and matched controls (n = 584) who remained free of CHD after a 10 year follow-up. Sitosterol-to-cholesterol ratios increased across tertiles of phytosterol intake ( P = 0.026). HDL-cholesterol level increased, and adiposity measures, cholesterol/HDL ratios, and levels of glucose, triglycerides, and lathosterol, a cholesterol synthesis marker, decreased across plasma sitosterol tertiles ( P
关键词：plant sterols ; sitosterol ; campesterol ; lathosterol ; cholesterol ; European Prospective Investigation into Cancer and Nutrition ; nested case-control study ; cardiometabolic risk ; apolipoprotein E