文章基本信息

标题：Genetic analysis of abdominal fat distribution in SM/J and A/J mice
本地全文：下载
作者：Misato Kobayashi ; Tamio Ohno ; Natsuko Hada 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2010
卷号：51
期号：12
页码：3463-3469
DOI：10.1194/jlr.M009563
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Each abdominal fat depot, such as mesenteric or epididymal, differently contributes to the development of insulin resistance. The aim of this study was to identify the genetic regions that contribute to fat accumulation in epididymal/mesenteric fat and to examine whether or not the genetic regions that affect glucose metabolism and body fat distribution are coincident. We previously mapped a major quantitative trait locus (QTL) ( T2dm2sa ) for impaired glucose tolerance on chromosome 2 and revealed that SM.A- T2dm2sa congenic mice showed not only glucose tolerance but also fat accumulation. In the present study, to identify the loci/genes that control the accumulation of abdominal fat, we perfomed QTL analyses of epididymal/mesenteric fat weight by using (A/J×SM.A- T2dm2sa )F2 mice in which the effect of T2dm2sa was excluded. As a result, two highly significant QTLs for mesenteric fat, as well as three significant QTLs for epididymal/mesenteric fat, were mapped on the different chromosomal regions. This suggests that the fat accumulations in individual fat depots are controlled by distinct genomic regions. Our comparison of these QTLs for abdominal fat distribution with those for glucose metabolism revealed that the major genetic factors affecting body fat distribution do not coincide with genetic factors affecting glucose metabolism in (A/J×SM.A- T2dm2sa )F2.
关键词：mesenteric fat ; epididymal fat ; glucose tolerance ; genetic factor