文章基本信息

标题：LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat
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作者：Chiara Degirolamo ; Gregory S. Shelness ; Lawrence L. Rudel 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：Supplement
页码：S434-S439
DOI：10.1194/jlr.R800076-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：This review focuses on the relationships among dietary fat type, plasma and liver lipid, and lipoprotein metabolism and atherosclerosis. Dietary polyunsaturated fatty acids are beneficial for the prevention of coronary artery atherosclerosis. By contrast, dietary monounsaturated fatty acids appear to alter hepatic lipoprotein metabolism, promote cholesteryl oleate accumulation, and confer atherogenic properties to lipoproteins as shown in data from experimental animal studies. Polyunsaturated fat appears to provide atheroprotection, at least in part, because it limits the accumulation of cholesteryl oleate in favor of cholesteryl linoleate in plasma lipoproteins.