文章基本信息

标题：Myeloperoxidase, modified lipoproteins, and atherogenesis
本地全文：下载
作者：Stephen J. Nicholls ; Stanley L. Hazen
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：Supplement
页码：S346-S351
DOI：10.1194/jlr.R800086-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These factors likely contribute to clinical studies demonstrating that increased systemic levels of MPO and its oxidation products predict increased cardiovascular risk. As a result, interest has focused on the potential to target MPO for the development of new risk markers, imaging, and therapies to prevent cardiovascular events.