文章基本信息

标题：Regulation of phospholipid synthesis in yeast
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作者：George M. Carman ; Gil-Soo Han
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：Supplement
页码：S69-S73
DOI：10.1194/jlr.R800043-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Phospholipid synthesis in the yeast Saccharomyces cerevisiae is a complex process that involves regulation by both genetic and biochemical mechanisms. The activity levels of phospholipid synthesis enzymes are controlled by gene expression (e.g., transcription) and by factors (lipids, water-soluble phospholipid precursors and products, and covalent modification of phosphorylation) that modulate catalysis. Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression.