文章基本信息

标题：Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
本地全文：下载
作者：Petra C. Kienesberger ; Monika Oberer ; Achim Lass 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：Supplement
页码：S63-S68
DOI：10.1194/jlr.R800082-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The human genome expresses nine patatin-like phospholipase domain containing proteins (PNPLA1–9). Members of this family share a protein domain discovered initially in patatin, the most abundant protein of the potato tuber. Patatin is a lipid hydrolase with an unusual folding topology that differs from classical lipases. Mammalian PNPLAs include lipid hydrolases with specificities for diverse substrates such as triacylglycerols, phospholipids, and retinol esters. Analysis of induced mutant mouse models and the clinical phenotype of patients with mutations revealed important insights into the physiological role of several members of the PNPLA family. This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis.