文章基本信息

标题：Lipoprotein lipase deficiency is associated with elevated acylation stimulating protein plasma levels
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作者：Sabina Paglialunga ; Pierre Julien ; Youssef Tahiri 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：6
页码：1109-1119
DOI：10.1194/jlr.M800430-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Acylation stimulating protein (ASP, C3adesArg) is an adipose tissue derived hormone that stimulates triglyceride (TG) synthesis. ASP stimulates lipoprotein lipase (LPL) activity by relieving feedback inhibition caused by fatty acids (FA). The present study examines plasma ASP and lipids in male and female LPL-deficient subjects primarily with the P207L mutation, common in the population of Quebec, Canada. We evaluated the fasting and postprandial states of LPL heterozygotes and fasting levels in LPL homozygotes. Homozygotes displayed increased ASP (58–175% increase, P P P P P