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标题：The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease
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作者：Guenther Silbernagel ; Guenter Fauler ; Wilfried Renner 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：2
页码：334-341
DOI：10.1194/jlr.P800013-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease (CAD) in 2,440 participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. The coronary status was determined by angiography, and the severity of CAD was assessed by the Friesinger Score (FS). An increase in the ratio of cholestanol to cholesterol was associated with high FS ( P = 0.006). In contrast, a high ratio of lathosterol to cholesterol went in parallel with low FS ( P P = 0.026), the relationship of the sitosterol to cholesterol ratio with the FS did not reach statistical significance in the whole group. Increased campesterol, sitosterol, and cholestanol to lathosterol ratios were associated high FS ( P