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标题：Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia
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作者：Marijn C. Meuwese ; Hans L. Mooij ; Max Nieuwdorp 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：1
页码：148-153
DOI：10.1194/jlr.P800025-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The endothelial glycocalyx has been shown to serve as a protective barrier between the flowing blood and the vessel wall in experimental models. The aim of this study was to evaluate whether hypercholesterolemia is associated with glycocalyx perturbation in humans, and if so, whether statin treatment can restore this. We measured systemic glycocalyx volume (V_G) in 13 patients with heterozygous familial hypercholesterolemia (FH) after cessation of lipid-lowering therapy for a minimum of 4 weeks and 8 weeks after initiating rosuvastatin therapy. Normocholesterolemic subjects were used as controls. V_G was estimated by subtracting the intravascular distribution volume of a glycocalyx permeable tracer (dextran 40) from that of a glycocalyx impermeable tracer (labeled erythrocytes). V_G in untreated FH patients [LDL 225 ± 57 mg/dl (mean ± SD)] was significantly reduced compared with controls (LDL 93 ± 24 mg/dl) (V_G 0.8 ± 0.3 vs. 1.7 ± 0.6, respectively, P G recovered only partially (V_G 1.1 ± 0.4 L, P = 0.04). The endothelial glycocalyx is profoundly reduced in FH patients, which may contribute to increased atherogenic vulnerability. This perturbation is partially restored upon short-term statin therapy.