文章基本信息

标题：Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats
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作者：Makoto Asahina ; Waka Haruyama ; Yasuhiro Ichida 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2009
卷号：50
期号：1
页码：41-46
DOI：10.1194/jlr.M800135-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation cross of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed interval-specific congenic lines and carried out expression and sequencing analyses. Here we narrowed Dihc2 to a region including 33 genes and predicted transcripts and identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.