文章基本信息

标题：Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance
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作者：Gissette Reyes ; Koichi Yasunaga ; Eileen Rothenstein 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2008
卷号：49
期号：3
页码：670-678
DOI：10.1194/jlr.P700019-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) = 503 ± 439] nor the TAG oil PPTG on a chronic DAG diet (AUC = 517 ± 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC = 565 ± 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels.