文章基本信息

标题：Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion
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作者：Uwe J. F. Tietge ; Niels Nijstad ; Rick Havinga 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2008
卷号：49
期号：3
页码：563-571
DOI：10.1194/jlr.M700276-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：High density lipoprotein cholesterol represents a major source of biliary cholesterol. Secretory phospholipase A₂ (sPLA₂) is an acute phase enzyme mediating decreased plasma HDL cholesterol levels. Clinical studies reported a link between increased sPLA₂ expression and the presence of cholesterol gallstones. The aim of our study was to investigate whether the overexpression of human sPLA₂ in transgenic mice affects biliary cholesterol secretion and gallstone formation. Liver weight ( P P 2 transgenic mice compared with controls as a result of increased scavenger receptor class B type I (SR-BI)-mediated hepatic selective uptake of HDL cholesterol ( P 2 transgenic mice. Furthermore, gallstone prevalence in response to a lithogenic diet was identical in both groups. These data demonstrate that i ) increased flux of cholesterol from HDL into the liver via SR-BI as a result of phospholipase modification of the HDL particle translates neither into increased biliary and fecal sterol output nor into increased gallstone formation, and ii ) increased sPLA₂ expression in patients with cholesterol gallstones might be a consequence rather than the underlying cause of the disease.