文章基本信息

标题：A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes
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作者：Carine Beysen ; Elizabeth J. Murphy ; Hirisadarahally Nagaraja 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2008
卷号：49
期号：12
页码：2657-2663
DOI：10.1194/jlr.M800165-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Treatment of type 2 diabetes mellitus (T2DM) patients with pioglitazone results in a more favorable lipid profile, and perhaps more favorable cardiac outcomes, than treatment with rosiglitazone. Pioglitazone treatment increases VLDL-triacylglycerol clearance, but the role of de novo lipogenesis (DNL) has not been explored, and no direct comparison has been made between the thiazolidinediones (TZDs). Twelve subjects with T2DM and hypertriacylglyceridemia were randomized to either rosiglitazone or pioglitazone treatment. Stable isotope infusion studies were performed at baseline and after 20 weeks of treatment. Both treatments reduced glucose and HbA_1c concentrations equally. Pioglitazone treatment resulted in a 40% reduction in hepatic DNL ( P P