出版社：American Society for Biochemistry and Molecular Biology
摘要：Abdominal obesity is associated with a decreased plasma concentration of HDL cholesterol and with qualitative modifications of HDL, such as triglyceride enrichment. Our aim was to determine, in isolated aorta rings, whether HDL from obese subjects can counteract the inhibitory effect of oxidized low density lipoprotein (OxLDL) on endothelium-dependent vasodilation as efficiently as HDL from normolipidemic, lean subjects. Plasma triglycerides were 74% higher ( P P E max ) = 82.1 ± 8.6% vs. 54.1 ± 8.1%; P E max = 47.2 ± 12.5% vs. 54.1 ± 8.1%; NS). In HDL from abdominally obese subjects compared with HDL from controls, the apoA-I content was 12% lower ( P P = 0.08)). E max (OxLDL + HDL) was correlated with HDL apoA-I content and triglyceride-to-cholesteryl ester ratio ( r = 0.36 and r = −0.38, respectively; P
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