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标题：The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis
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作者：Jeltje R. Goudriaan ; Sonia M. S. Espirito Santo ; Peter J. Voshol 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：8
页码：1475-1481
DOI：10.1194/jlr.M400009-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived FFA by facilitating the expression of lipoprotein lipase (LPL). However, vldlr ⁻ ^{/ −} mice do not show altered plasma lipoprotein levels, despite reduced LPL expression. Because LPL activity is crucial in postprandial lipid metabolism, we investigated whether the VLDLr plays a role in chylomicron clearance. Fed plasma TG levels of vldlr ⁻ ^{/ −} mice were 2.5-fold increased compared with those of vldlr ⁺ ^{/ +} littermates (1.20 ± 0.37 mM vs. 0.47 ± 0.18 mM; P vldlr ⁻ ^{/ −} compared with vldlr ⁺ ^{/ +} mice (226 ± 188 mM/h vs. 25 ± 11 mM/h; P 3H]TG-labeled protein-free chylomicron-mimicking emulsion particles was delayed in vldlr ⁻ ^{/ −} compared with vldlr ⁺ ^{/ +} mice (half-life of 12.0 ± 2.6 min vs. 5.5 ± 0.9 min; P P 14C]FFA, indicating that the VLDLr facilitates postprandial LPL-mediated TG hydrolysis rather than mediating FFA uptake. We conclude that the VLDLr plays a major role in the metabolism of postprandial lipoproteins by enhancing LPL-mediated TG hydrolysis.