文章基本信息

标题：Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men
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作者：Graham C. Burdge ; Berit Lupoli ; Jennifer J. Russell 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：4
页码：736-741
DOI：10.1194/jlr.M300447-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：This study investigated the incorporation of cis -9, trans -11 conjugated linoleic acid (c9,t11 CLA) and trans -10, cis -12-CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids when consumed as supplements highly enriched in these isomers. Healthy men (n = 49, age 31 ± 8 years) consumed one, two, and four capsules containing ∼600 mg of either c9,t11 CLA or t10,c12 CLA per capsule for sequential 8 week periods followed by a 6 week washout before consuming the alternative isomer. Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r = 0.779, t10,c12 CLA r = 0.738; P r = 0.706, t10,c12 CLA r = 0.788; P r = 0.285 and r = 0.273, respectively; P These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily.