文章基本信息

标题：Differential effects of the C1431T and Pro12Ala PPARγ gene variants on plasma lipids and diabetes risk in an Asian population
本地全文：下载
作者：E. Shyong Tai ; Dolores Corella ; Mabel Deurenberg-Yap 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：4
页码：674-685
DOI：10.1194/jlr.M300363-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：We investigated the association of C1431T and Pro12Ala polymorphisms at the peroxisome proliferator-activated receptor γ (PPARγ) locus with plasma lipids and insulin resistance-related variables, according to diabetes status, in a large and representative Asian population from Singapore consisting of 2,730 Chinese, 740 Malays, and 568 Indians. Moreover, we estimated the diabetes risk and examined gene-nutrient interactions between these variants and the ratio of polyunsaturated fatty acid to saturated fat (SFA) in determining body mass index (BMI) and fasting insulin. We found differential effects of these gene variants. The Pro12Ala polymorphism was more associated with plasma lipids and fasting glucose concentrations, whereas the C1431T polymorphism was related to the risk of diabetes. Carriers of the 12Ala allele had higher HDL-cholesterol than did Pro12Pro homozygotes ( P P P = 0.011]; this effect was stronger in Indians (OR 0.38, 95% CI 0.15–0.92; P = 0.032). For both polymorphisms, normal subjects carrying the less prevalent allele had higher BMI ( P