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标题：Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample
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作者：Minna T. Jänis ; Sarah Siggins ; Esa Tahvanainen 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：12
页码：2303-2309
DOI：10.1194/jlr.M400250-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Human serum phospholipid transfer protein (PLTP) exists as a catalytically active (HA-PLTP) and a low-active (LA-PLTP) form. In this study, the association of PLTP activity and the concentrations of both forms with lipid and carbohydrate parameters were investigated. In a random Finnish population sample, serum PLTP concentration (n = 250) was 6.56 ± 1.45 mg/l, the mean lipoprotein-independent (PLTP_exo) phospholipid transfer activity was 6.59 ± 1.66 μmol/ml/h, and the mean lipoprotein-dependent (PLTP_endo) activity was 1.37 ± 0.29 μmol/ml/h. Of the serum PLTP concentration, ∼46% was in a catalytically active form. HA-PLTP concentration correlated positively with serum PLTP_exo activity ( r = 0.380, P r = 0.291, P r = 0.187, P exo ( r = 0.154, P endo ( r = 0.192, P The present data on PLTP activity and concentration reveal novel connections of the two PLTP forms to lipid and carbohydrate metabolism.