文章基本信息

标题：Overexpression of apoC-III produces lesser hypertriglyceridemia in apoB-48-only gene-targeted mice than in apoB-100-only mice
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作者：Karin Conde-Knape ; Kenta Okada ; Rajasekhar Ramakrishnan 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：12
页码：2235-2244
DOI：10.1194/jlr.M400185-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：The adaptive value of apolipoprotein B-48 (apoB-48), the truncated form of apoB produced by the intestine, in lipid metabolism remains unclear. We crossed human apoC-III transgenic mice with mice expressing either apoB-48 only ( apoB ^48/48) or apoB-100 only ( apoB ^100/100). Cholesterol levels were higher in apoB ^48/48 mice than in apoB ^100/100 mice but triglyceride levels were similar. Lipid levels were increased by the apoC-III transgene. However, triglyceride levels were significantly higher in apoB ^100/100C-III than in apoB ^48/48C-III mice (895 ± 395 mg/dl vs. 690 ± 252 mg/dl; P apoB ^48/48C-III mice than in apoB ^100/100C-III (144 ± 35 mg/dl vs. 94 ± 30 mg/dl; P apoB ^100/100C-III vs. apoB ^100/100 mice than in apoB ^48/48C-III vs. apoB ^48/48 mice. Triglyceride secretion rates were no different in apoC-III transgenic mice than in their nontransgenic littermates. ApoB-48 triglyceride-rich lipoproteins were more resistant to the triglyceride-increasing effects of apoC-III but appeared more sensitive to the remnant clearance inhibition. Our findings support a coordinated role for apoB-48 in facilitating the delivery of dietary triglycerides to the periphery. Consistent with such a mechanism, glucose levels were significantly higher in apoB ^48/48 mice vs. apoB ^100/100 mice, perhaps on the basis of metabolic competition.