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标题：Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica
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作者：Yadong Yang ; Edward Ruiz-Narvaez ; Tianhua Niu 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：11
页码：2106-2109
DOI：10.1194/jlr.M400202-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：To assess common variants of the LPL gene that could influence susceptibility to myocardial infarction (MI), we assessed three functional single-nucleotide polymorphisms (SNPs), D9N, N291S, and S447X, in 1,321 survivors of a first acute MI and 1,321 population-based controls, matched for age, gender, and area of residence, all living in the Central Valley of Costa Rica. Conditional logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI). The frequency of the X447 mutant allele was significantly lower in cases than in controls (6.2% vs. 7.6%; P The X447 mutant allele of the LPL gene may protect from MI risk, although this effect is small.