文章基本信息

标题：Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia
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作者：Stefan Bilz ; Stephan Wagner ; Michaela Schmitz 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：1
页码：174-185
DOI：10.1194/jlr.M300309-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Kinetics of apo B and apo AI were assessed in 8 patients with mixed hyperlipidemia at baseline and after 8 weeks of atorvastatin 80 mg q.d. and micronised fenofibrate 200 mg q.d. in a cross-over study. Both increased hepatic production and decreased catabolism of VLDL accounted for elevated cholesterol and triglyceride concentrations at baseline. Atorvastatin significantly decreased triglyceride, total, VLDL and LDL cholesterol and apo B concentrations (−65%, −36%, −57%, −40% and −33%, respectively, P 1 and decreased VLDL₁ production. Fenofibrate lowered triglycerides and VLDL cholesterol (−57% and −64%, respectively, P 1 and VLDL₂ and increased VLDL₁ catabolism. Changes of HDL particle composition accounted for the increase of HDL cholesterol during atorvastatin and fenofibrate (18% and 23%, P P We conclude that atorvastatin exerts additional beneficial effects on the metabolism of apo B containing lipoproteins unrelated to an increase in LDL receptor activity. Fenofibrate but not atorvastatin increases apo AI production and plasma turnover.