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标题：Periodontitis decreases the antiatherogenic potency of high density lipoprotein
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作者：Pirkko J. Pussinen ; Matti Jauhiainen ; Tiina Vilkuna-Rautiainen 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2004
卷号：45
期号：1
页码：139-147
DOI：10.1194/jlr.M300250-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Periodontitis, a consequence of persistent bacterial infection and chronic inflammation, has been suggested to predict coronary heart disease (CHD). The aim of this study was to investigate the impact of periodontitis on HDL structure and antiatherogenic function in cholesterol efflux in vitro. HDL was isolated from 30 patients (age 43.6 ± 6.1 years, mean ± SD) with periodontitis before and after (3.2 ± 1.4 months) periodontal treatment. The capacity of HDL for cholesterol efflux from macrophages (RAW 264.7), HDL composition, and key proteins of HDL metabolism were determined. After periodontal treatment, phospholipid transfer protein (PLTP) activity was 6.2% ( P P P = 0.078), and 19.4% ( P 2/HDL₃ ratio increased from 2.16 ± 0.87 to 3.56 ± 0.48 ( P P P P P = 0.015) and who were positive by PCR for Actinobacillus actinomycetemcomitans . These results suggest that periodontitis causes similar, but milder, changes in HDL metabolism than those that occur during the acute-phase response and that periodontitis may diminish the antiatherogenic potency of HDL, thus increasing the risk for CHD.