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标题：Effect of atorvastatin on postprandial lipoprotein metabolism in hypertriglyceridemic patients
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作者：Klaus G. Parhofer ; Ester Laubach ; P. Hugh R. Barrett 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2003
卷号：44
期号：6
页码：1192-1198
DOI：10.1194/jlr.M300011-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Postprandial lipoprotein metabolism is impaired in hypertriglyceridemia. It is unknown how and to what extent atorvastatin affects postprandial lipoprotein metabolism in hypertriglyceridemic patients. We evaluated the effect of 4 weeks of atorvastatin therapy (10 mg/day) on postprandial lipoprotein metabolism in 10 hypertriglyceridemic patients (age, 40 ± 3 years; body mass index, 27 ± 1 kg/m²; cholesterol, 5.74 ± 0.34 mmol/l; triglycerides, 3.90 ± 0.66 mmol/l; HDL-cholesterol, 0.85 ± 0.05 mmol/l; and LDL-cholesterol, 3.18 ± 0.23 mmol/l). Patients were randomized to be studied with or without atorvastatin therapy. Postprandial lipoprotein metabolism was evaluated with a standardized oral fat load. Plasma was obtained every 2 h for 14 h. Large triglyceride-rich lipoproteins (TRLs) (containing chylomicrons) and small TRLs (containing chylomicron remnants) were isolated by ultracentrifugation, and cholesterol, triglyceride, apolipoprotein B-100 (apoB-100), apoB-48, apoC-III, and retinyl-palmitate concentrations were determined. Atorvastatin significantly ( P P We conclude that atorvastatin improves postprandial lipoprotein metabolism in addition to decreasing fasting lipid levels in hypertriglyceridemia. Such changes would be expected to improve the atherogenic profile.