文章基本信息

标题：Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease
本地全文：下载
作者：S. Matthijs Boekholdt ; John F. Thompson
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2003
卷号：44
期号：6
页码：1080-1093
DOI：10.1194/jlr.R200018-JLR200
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Since the identification of cholesteryl ester transfer protein (CETP), its role in the modulation of HDL levels and cardiovascular disease has been debated. With the early detection of genetic variants followed by the finding of families deficient in CETP, genetic studies have played a large role in the attempts to understand the association of CETP with lipids and disease; however, results of these studies have often led to disparate conclusions. With the availability of a greater variety of genetic polymorphisms and larger studies in which disease has been examined, it is now possible to compare the breadth of CETP genetic studies and draw better conclusions. The most broadly studied polymorphism is TaqIB for which over 10,000 individuals have been genotyped and had HDL levels determined. When these studies are subjected to a meta-analysis, the B2B2 homozygotes are found to have higher HDL levels than B1B1 homozygotes (0.12 mmol/l, 95% CI = 0.11–0.13, P P The implications of these studies for cardiovascular disease will be addressed.